EL CATÁLOGO

28 Sistemas Operativos de Dominio. Una pila compuesta.

Cada DomainOS es una capa fina sobre plugins de razonamiento compartidos y la capa de datos MCP. Diseñados para un dominio científico — genómica, CRISPR, descubrimiento de fármacos, clínica — con aprobación humana en cada decisión crítica.

Explorar CRISPRos Ver los 28 dominios

Los productos DomainOS son sistemas operativos de dominio construidos sobre plugins de razonamiento compartidos y una capa de datos MCP verificada. Voltea cualquier tarjeta para ver herramientas integradas y un ejemplo real.

EL CATÁLOGO

Cada dominio. Cada flujo. Un manifiesto de procedencia.

Siete categorías, 28 sistemas operativos, 1.062+ skills. Haz clic en cualquier tarjeta para ver sus herramientas integradas, entradas y salidas, y un flujo de ejemplo.

Genómica y variantes

8 productos

Genomics & Variants

Beta

BIOos

Alignment, QC, RNA-seq

8 agentes · 92 habilidades · 3 MCPs · 3 controles HITL

BIOos

Beta

8 agentes

92 habilidades

3 MCPs

3 controles HITL

FASTQ · Reference genome · Sample sheet

Out

BAM/CRAM · MultiQC report · Count matrix

Herramientas integradas

STAR BWA-MEM2 samtools MultiQC

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Align a 50-sample RNA-seq cohort with provenance-tracked QC gates.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Genomics & Variants

Beta

GWASos

Association, fine-mapping

7 agentes · 78 habilidades · 3 MCPs · 3 controles HITL

Abrir →

GWASos

Beta

7 agentes

78 habilidades

3 MCPs

3 controles HITL

PLINK/VCF · Phenotype table · Covariates

Out

Summary stats · Manhattan plot · Credible sets

Herramientas integradas

PLINK2 REGENIE SAIGE SuSiE

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Run a biobank-scale association with calibrated inflation checks.

Emite manifest.json · SHA-256 por artefacto

Abrir docs →

Genomics & Variants

Beta

varfx-os

Variant annotation

6 agentes · 61 habilidades · 3 MCPs · 2 controles HITL

varfx-os

Beta

6 agentes

61 habilidades

3 MCPs

2 controles HITL

VCF · Gene models

Out

Annotated VCF · Effect tiers · Evidence trail

Herramientas integradas

VEP SnpEff AlphaMissense

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Prioritize coding + regulatory variants with grounded effect calls.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Genomics & Variants

Beta

finemap-os

Statistical fine-mapping

5 agentes · 54 habilidades · 3 MCPs · 2 controles HITL

finemap-os

Beta

5 agentes

54 habilidades

3 MCPs

2 controles HITL

GWAS summary stats · LD reference

Out

Credible sets · Posterior probs · Locus plots

Herramientas integradas

SuSiE FINEMAP CAVIAR PolyFun

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Narrow a GWAS locus to a handful of credible causal variants.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Genomics & Variants

Beta

prs-os

Polygenic risk scores

4 agentes · 47 habilidades · 3 MCPs · 2 controles HITL

prs-os

Beta

4 agentes

47 habilidades

3 MCPs

2 controles HITL

GWAS weights · Target genotypes

Out

PRS per sample · Calibration plot · Ancestry audit

Herramientas integradas

PRS-CS LDpred2 PLINK2

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Derive a cross-ancestry PRS with bias and calibration diagnostics.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Genomics & Variants

Beta

mendel-os

Mendelian genetics

5 agentes · 52 habilidades · 3 MCPs · 3 controles HITL

mendel-os

Beta

5 agentes

52 habilidades

3 MCPs

3 controles HITL

Pedigree · Trio VCF · HPO terms

Out

Candidate variants · Inheritance fit · ACMG class

Herramientas integradas

Exomiser GEMINI Phen2Gene

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Narrow a trio exome to a ranked list of Mendelian candidates.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Genomics & Variants

Beta

clinvar-os

ClinVar interpretation

4 agentes · 39 habilidades · 3 MCPs · 3 controles HITL

clinvar-os

Beta

4 agentes

39 habilidades

3 MCPs

3 controles HITL

VCF · Variant IDs

Out

ClinVar evidence · Conflict report · Citation trail

Herramientas integradas

ClinVar LitVar OMIM

Servidores MCP

biocontext7 ClinicalTrials PubMed

Ejemplo

Audit clinical variant interpretations against latest ClinVar evidence.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Genomics & Variants

Beta

longread-os

ONT, PacBio

5 agentes · 58 habilidades · 3 MCPs · 2 controles HITL

longread-os

Beta

5 agentes

58 habilidades

3 MCPs

2 controles HITL

Nanopore / HiFi FASTQ · Reference

Out

Phased BAM · SV VCF · Methylation BED

Herramientas integradas

minimap2 Sniffles Clair3 Nanopolish

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Phase a long-read genome and resolve structural variants end to end.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Célula y molecular

4 productos

Cell & Molecular

Beta

CRISPRos

Guide design, knockouts

8 agentes · 86 habilidades · 3 MCPs · 4 controles HITL

Abrir →

CRISPRos

Beta

8 agentes

86 habilidades

3 MCPs

4 controles HITL

Target gene(s) · Cell line · Delivery context

Out

Guide library · Off-target report · Experiment manifest

Herramientas integradas

CRISPOR CHOPCHOP FlashFry Azimuth

Servidores MCP

biocontext7 PubMed Knowledge Graph

Ejemplo

Design a tiled knockout library with human approval at every gate.

Emite manifest.json · SHA-256 por artefacto

Abrir docs →

Cell & Molecular

Beta

screen-os

CRISPR screens, MAGeCK

6 agentes · 64 habilidades · 3 MCPs · 3 controles HITL

screen-os

Beta

6 agentes

64 habilidades

3 MCPs

3 controles HITL

Counts matrix · Library design · Conditions

Out

Hit list · Gene-level scores · QC dashboard

Herramientas integradas

MAGeCK BAGEL drugZ ScreenPro2

Servidores MCP

biocontext7 PubMed BioRender

Ejemplo

Run a pooled CRISPR screen from counts to ranked, evidence-grounded hits.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Cell & Molecular

Beta

cell-os

Cell biology analysis

6 agentes · 71 habilidades · 3 MCPs · 2 controles HITL

cell-os

Beta

6 agentes

71 habilidades

3 MCPs

2 controles HITL

scRNA / sc-ATAC counts · Sample metadata

Out

Annotated atlas · Marker panels · Trajectory

Herramientas integradas

Scanpy Seurat scVI CellTypist

Servidores MCP

biocontext7 PubMed BioRender

Ejemplo

Annotate a single-cell atlas with reproducible cell-type calls.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Cell & Molecular

Beta

spatial-os

Spatial transcriptomics

4 agentes · 48 habilidades · 3 MCPs · 2 controles HITL

spatial-os

Beta

4 agentes

48 habilidades

3 MCPs

2 controles HITL

Visium / Xenium / MERFISH · H&E image

Out

Niche map · Co-localization · Cell-cell signals

Herramientas integradas

Squidpy CellCharter SpatialData SOPA

Servidores MCP

biocontext7 PubMed BioRender

Ejemplo

Map tissue niches and cell-cell communication across spatial slides.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Ómicas

5 productos

Omics

Beta

onco-os

Somatic, neoantigen

6 agentes · 68 habilidades · 4 MCPs · 3 controles HITL

onco-os

Beta

6 agentes

68 habilidades

4 MCPs

3 controles HITL

Tumor/normal BAM · HLA type

Out

Somatic VCF · Neoantigens · Signatures

Herramientas integradas

Mutect2 pVACtools SigProfiler MSIsensor

Servidores MCP

biocontext7 ChEMBL PubMed Paper Intelligence

Ejemplo

Profile a tumor from raw reads through prioritized neoantigens.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Omics

Beta

microbiome-os

16S, metagenomics

5 agentes · 55 habilidades · 3 MCPs · 2 controles HITL

microbiome-os

Beta

5 agentes

55 habilidades

3 MCPs

2 controles HITL

16S / shotgun FASTQ · Sample metadata

Out

ASV table · Taxonomy · Function profile

Herramientas integradas

QIIME 2 Kraken2 HUMAnN MetaPhlAn

Servidores MCP

biocontext7 PubMed Paper Intelligence

Ejemplo

Go from raw microbiome reads to differential-abundance figures.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Omics

Beta

proteomics-os

Mass spec

4 agentes · 46 habilidades · 3 MCPs · 2 controles HITL

proteomics-os

Beta

4 agentes

46 habilidades

3 MCPs

2 controles HITL

RAW / mzML · Sample design

Out

Protein matrix · PTM sites · Differential report

Herramientas integradas

MaxQuant FragPipe DIA-NN MSstats

Servidores MCP

biocontext7 PubMed Paper Intelligence

Ejemplo

Quantify a label-free proteomics cohort with PTM-aware QC.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Omics

Beta

metab-os

Metabolomics

4 agentes · 42 habilidades · 3 MCPs · 2 controles HITL

metab-os

Beta

4 agentes

42 habilidades

3 MCPs

2 controles HITL

LC-MS / NMR · Metadata

Out

Feature table · Annotations · Pathway enrichment

Herramientas integradas

XCMS MS-DIAL MetaboAnalyst GNPS

Servidores MCP

biocontext7 PubMed Paper Intelligence

Ejemplo

Annotate and contextualize untargeted metabolomics features.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Omics

Beta

immuno-os

Immune repertoire

4 agentes · 44 habilidades · 3 MCPs · 2 controles HITL

immuno-os

Beta

4 agentes

44 habilidades

3 MCPs

2 controles HITL

TCR / BCR sequencing · Clonal metadata

Out

Clonotype table · Diversity stats · V(D)J map

Herramientas integradas

MiXCR TRUST4 Immcantation scirpy

Servidores MCP

biocontext7 PubMed Paper Intelligence

Ejemplo

Characterize TCR/BCR repertoire dynamics across treatment arms.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Imagen y estructura

2 productos

Imaging & Structure

Beta

struct-os

AlphaFold, docking

5 agentes · 59 habilidades · 4 MCPs · 2 controles HITL

struct-os

Beta

5 agentes

59 habilidades

4 MCPs

2 controles HITL

Sequence · Ligand SMILES · Target PDB

Out

Predicted structure · Pocket map · Docked poses

Herramientas integradas

AlphaFold3 ESMFold Boltz-1 DiffDock

Servidores MCP

biocontext7 PubMed BioRender Knowledge Graph

Ejemplo

Fold a target, find its pocket, and screen candidate binders.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Imaging & Structure

Beta

bioimage-os

Microscopy

5 agentes · 51 habilidades · 3 MCPs · 2 controles HITL

bioimage-os

Beta

5 agentes

51 habilidades

3 MCPs

2 controles HITL

TIFF / OME-Zarr · Channel metadata

Out

Segmentation · Morphometrics · Tracking

Herramientas integradas

CellProfiler Cellpose StarDist napari

Servidores MCP

biocontext7 PubMed BioRender

Ejemplo

Segment and quantify phenotypes across high-content imaging plates.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Clínica y regulación

3 productos

Clinical & Regulatory

Beta

rare-os

Rare disease, ACMG

5 agentes · 57 habilidades · 3 MCPs · 4 controles HITL

rare-os

Beta

5 agentes

57 habilidades

3 MCPs

4 controles HITL

Proband VCF · HPO phenotypes · Trio (optional)

Out

ACMG classification · Candidate list · Report draft

Herramientas integradas

Exomiser InterVar VarSome Franklin

Servidores MCP

ClinicalTrials PubMed Knowledge Graph

Ejemplo

Generate an ACMG-graded rare disease report with traceable evidence.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Clinical & Regulatory

Beta

clinical-os

EHR, PyHealth

4 agentes · 49 habilidades · 3 MCPs · 3 controles HITL

clinical-os

Beta

4 agentes

49 habilidades

3 MCPs

3 controles HITL

FHIR / OMOP CDM · Cohort criteria

Out

Cohort table · Endpoint schedule · Audit log

Herramientas integradas

PyHealth OHDSI CEDAR Synthea

Servidores MCP

ClinicalTrials PubMed Synapse

Ejemplo

Build an OMOP cohort with endpoints that survive regulatory audit.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Clinical & Regulatory

Beta

reg-os

ISO 13485, FDA QMSR

4 agentes · 41 habilidades · 3 MCPs · 4 controles HITL

reg-os

Beta

4 agentes

41 habilidades

3 MCPs

4 controles HITL

Requirements · Test records · Change log

Out

DHF package · Traceability matrix · Submission draft

Herramientas integradas

ISO 13485 FDA QMSR IEC 62304

Servidores MCP

ClinicalTrials PubMed Synapse

Ejemplo

Compile a design-history file with claim-to-evidence traceability.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Descubrimiento de fármacos

3 productos

Drug Discovery

Beta

chem-os

Cheminformatics

5 agentes · 50 habilidades · 3 MCPs · 2 controles HITL

chem-os

Beta

5 agentes

50 habilidades

3 MCPs

2 controles HITL

SMILES · Assay readouts

Out

Property table · Scaffold map · SAR summary

Herramientas integradas

RDKit ChEMBL DataWarrior Reaxys

Servidores MCP

ChEMBL PubMed Paper Intelligence

Ejemplo

Triage a library and pull out scaffold-level SAR trends.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Drug Discovery

Beta

admet-os

ADMET prediction

4 agentes · 45 habilidades · 3 MCPs · 3 controles HITL

admet-os

Beta

4 agentes

45 habilidades

3 MCPs

3 controles HITL

SMILES · Reference compounds

Out

ADMET profile · Alert flags · Confidence bands

Herramientas integradas

ADMET-AI SwissADME TDC DeepPurpose

Servidores MCP

ChEMBL PubMed Paper Intelligence

Ejemplo

Profile ADMET liabilities with calibrated uncertainty, not point estimates.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Drug Discovery

Beta

virtual-screen-os

Virtual screening

4 agentes · 48 habilidades · 3 MCPs · 2 controles HITL

virtual-screen-os

Beta

4 agentes

48 habilidades

3 MCPs

2 controles HITL

Target structure · Compound library

Out

Ranked hits · Pose library · Enrichment report

Herramientas integradas

AutoDock Vina GNINA DiffDock DeepDock

Servidores MCP

ChEMBL PubMed Knowledge Graph

Ejemplo

Dock a million compounds and surface high-confidence candidates.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Sistemas y redes

3 productos

Systems & Networks

Beta

systems-os

Systems biology

4 agentes · 43 habilidades · 3 MCPs · 2 controles HITL

systems-os

Beta

4 agentes

43 habilidades

3 MCPs

2 controles HITL

Expression matrix · Perturbation data

Out

Causal graph · Intervention plan · Model fit

Herramientas integradas

CellOracle COBRA Tellurium GeneFormer

Servidores MCP

Knowledge Graph PubMed Paper Intelligence

Ejemplo

Build a causal systems model that predicts perturbation response.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Systems & Networks

Beta

pathway-os

Pathway analysis

4 agentes · 40 habilidades · 3 MCPs · 2 controles HITL

pathway-os

Beta

4 agentes

40 habilidades

3 MCPs

2 controles HITL

Gene lists · Expression data

Out

Enriched pathways · Network figure · Citation trail

Herramientas integradas

Reactome GSEA enrichR WebGestalt

Servidores MCP

Knowledge Graph PubMed Paper Intelligence

Ejemplo

Convert a gene hit list into a pathway narrative grounded in citations.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

Systems & Networks

Beta

grn-os

Gene regulatory networks

4 agentes · 46 habilidades · 3 MCPs · 2 controles HITL

grn-os

Beta

4 agentes

46 habilidades

3 MCPs

2 controles HITL

scRNA + ATAC · TF motif database

Out

Regulon set · TF targets · Perturbation predictions

Herramientas integradas

SCENIC+ Pando GRNBoost2 CellOracle

Servidores MCP

Knowledge Graph PubMed Paper Intelligence

Ejemplo

Infer TF regulons from multiomic data and simulate knockouts.

Emite manifest.json · SHA-256 por artefacto

Solicitar acceso →

28 Sistemas Operativos de Dominio · Recuentos a Q2 2026 · Haz clic en cualquier tarjeta para ver integraciones y un flujo de ejemplo

LA CAPA DE RAZONAMIENTO

Cinco plugins que Claude compone en cada ejecución.

Los productos DomainOS despachan a una capa de razonamiento compartida: cinco plugins que Claude compone en cada ejecución. Cada uno resuelve un problema científico difícil.

Plugin de razonamiento

Beta

co-writer

Compiles scientific writing

Compiles submission-grade papers, grants, biosketches, and CVs from structured intent and lab data. Every output compiled from artifacts, with claim-to-evidence tracking and venue formatting.

34 habilidades · 5 agentes · 3 MCPs

co-writer

Compiles scientific writing

Beta

34 habilidades

5 agentes

3 MCPs

Habilidades clave

compile-manuscript evidence-audit compliance-lint citation-resolve

Agentes

citation-resolver science-reviewer reviewer-simulator diff-presenter compiler-orchestrator

Servidores MCP

PubMed Paper Intelligence bioRxiv

Ejemplo

Compile an R01 renewal from lab data, prior papers, and aims — every sentence cited to a source artifact.

Emite: claim-to-evidence map + manifest.json

plugin/co-writer

Plugin de razonamiento

Beta

co-scientist

Generates and critiques hypotheses

Hypothesis-driven research assistant. Generates, critiques, and evaluates hypotheses using the Swanson ABC model across a 6-phase pipeline — Scout → Generate → Critique → Scan → Plan → Review — with Elo tournament ranking.

8 habilidades · 7 agentes · 4 MCPs

co-scientist

Generates and critiques hypotheses

Beta

8 habilidades

7 agentes

4 MCPs

Habilidades clave

hypothesis-generate hypothesis-critique novelty-scan analysis-plan

Agentes

research-copilot hypothesis-generator hypothesis-critic hypothesis-evaluator hypothesis-evolver debate-orchestrator tournament-ranker

Servidores MCP

PubMed bioRxiv Paper Intelligence Knowledge Graph

Ejemplo

Explore 'cold target' hypotheses for a rare disease with Elo-ranked debate between generator and critic agents.

Emite: HypothesisIR + DebateRecord + Elo ranking

plugin/co-scientist

Plugin de razonamiento

Beta

sophia-claudette

Audits scientific reasoning

Scientific reasoning plugin for Claude Code. Runs as automatic background observations and an explicit deep mode — uncertainty calibration, causal skepticism, drift auditing, epistemic diagnostics.

7 habilidades · 9 agentes · 2 MCPs

sophia-claudette

Audits scientific reasoning

Beta

7 habilidades

9 agentes

2 MCPs

Habilidades clave

uncertainty-calibration causal-skepticism drift-audit decision-audit

Agentes

socratic-facilitator epistemic-diagnostician evidence-curator causal-skeptic experimental-designer uncertainty-calibrator decision-auditor +2

Servidores MCP

Paper Intelligence PubMed

Ejemplo

Flag correlation-vs-causation drift in a mid-flight manuscript before it ships to peer review.

Emite: epistemic card + drift log

plugin/sophia-claudette

Plugin de razonamiento

Beta

paper-intelligence

Extracts and tracks claims

Extracts structured claims from scientific papers, builds evidence graphs, and queries claim relationships. Seven-stage ingestion: ingest → extract → normalize → dedup → link → tag → upsert. Provenance is never fabricated.

12 habilidades · 3 agentes · 4 MCPs

paper-intelligence

Extracts and tracks claims

Beta

12 habilidades

3 agentes

4 MCPs

Habilidades clave

paper-ingest claim-extract contradiction-detection claim-graph-query

Agentes

paper-intelligence-agent graph-builder claim-graph-builder

Servidores MCP

PubMed bioRxiv Paper Intelligence Knowledge Graph

Ejemplo

Ingest 40 papers on BRCA1 synthetic lethality and surface contradictions across the claim graph.

Emite: claim graph + provenance chain per claim

plugin/paper-intelligence

Plugin de razonamiento

Beta

knowledge-graph

Unifies biomedical knowledge

Universal biomedical knowledge graph infrastructure. Neo4j graph + DuckDB columnar + SQLite FTS5 text search, Biolink Model schema, namespace-isolated across pi, t1d, gwas, crispr, tools, hyp, skill.

5 habilidades · 1 agentes · 4 MCPs

knowledge-graph

Unifies biomedical knowledge

Beta

5 habilidades

1 agentes

4 MCPs

Habilidades clave

graph-query graph-ingest graph-search graph-explore

Agentes

graph-builder

Servidores MCP

Knowledge Graph PubMed ChEMBL Paper Intelligence

Ejemplo

Unify GWAS loci, tissue expression, and drug targets into one queryable graph for target selection.

Emite: Biolink-schema graph + citation edges

plugin/hordago-knowledge-graph

Ver cómo se componen las capas

Lleva IA basada en evidencia a tu laboratorio.

Trabajamos con laboratorios académicos, biotechs, programas gubernamentales y equipos industriales de ciencias de la vida. Dinos el dominio; mapearemos el DomainOS, motores y controles humanos adecuados.

Contáctanos Leer la arquitectura