OUR PLATFORM
Three layers. One scientific platform.
Hordago separates product shells, scientific engines, and execution infrastructure. This allows new domain products to be generated without rebuilding the stack from scratch.
Platform Architecture
Built in Layers
Domain Operating Systems
Shared Scientific Engines
Factory & Execution
LAYER 1
Domain Operating Systems
Purpose-built operating systems for specific scientific domains. Thin shells powered by shared engines.
CRISPRos
CRISPR Experiment Operating System
End-to-end CRISPR perturbation workflows with human approval at every decision gate. Full provenance on every experiment.
GWASos
GWAS Analysis Operating System
AI-assisted rare variant prioritization with human-verified regulatory effect predictions. Calibrated uncertainty for confident target selection.
LAYER 2
Shared Scientific Engines
The reusable substrate that powers every DomainOS product.
co-writer
Scientific Writing Engine
Evidence-locked manuscript drafting. 34 skills, 5 agents. Artifacts, not hallucination.
co-scientist
Hypothesis Discovery Engine
6-phase pipeline with Elo tournament ranking for hypothesis selection. 8 skills, 7 agents.
sophia-claudette
Epistemic Reasoning Engine
Uncertainty calibration, causal skepticism, drift auditing. 7 skills, 9 agents.
paper-intelligence
Claim Extraction Engine
Structured claim graphs, contradiction detection, citation networks. 12 skills, 3 agents, 5 MCP.
knowledge-graph
Biomedical Knowledge Graph
Neo4j + DuckDB + FTS5 across 7 namespaces. 5 skills, 1 agent, 11 MCP tools.
biocontext7
Deep Skill Bundles
2,000+ hash-verified bioinformatics skill bundles served via MCP. External MCP server.
LAYER 3
Factory & Execution
How Hordago manufactures scientific products.
Scientific Compiler
Deterministic Build System
Spec Engine
Work Decomposition
Agentic Orchestration
Parallel Execution
THE FLYWHEEL
How DomainOS products learn
Every experiment makes the system smarter.
Prioritize
Foundation models score rare variants and predict regulatory effects with calibrated uncertainty
Plan
Agentic workflows generate optimized CRISPR perturbation strategies and protocols
Execute
Experiments run with full provenance capture, tracking every parameter and condition
Learn
Outcomes feed back to improve predictions, closing the loop for continuous improvement
SECURITY & COMPLIANCE
Built for regulated environments.
Enterprise-grade security and compliance infrastructure designed for life sciences research.
Data Privacy
All data processing with your own API keys — nothing stored on our servers. Your research data never leaves your infrastructure.
Full Provenance
Every output includes a cryptographic manifest: inputs, git commits, tool versions, environment, and SHA-256 hashes for complete auditability.
Access Controls
Role-based access with human approval gates at every critical decision point. AI proposes, scientists decide.
Ready to accelerate your research?
Learn how our platform can transform your scientific workflows.